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Vol. 20 No. 2, August 2008
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AAP Grand Rounds 20:16-17 (2008)
© 2008 American Academy of Pediatrics

CRITICAL CARE

Corticosteroids and Mortality in Children With Bacterial Meningitis

Source: Mongelluzzo J, Mohamad Z, Ten Have TR, et al. Corticosteroids and mortality in children with bacterial meningitis. JAMA 2008;299(17):2048–2055; doi:10.1001/jama.299.17.2048[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Among children with bacterial meningitis, does corticosteroid administration within the first 24 hours of admission decrease mortality or length of hospital stay?

Question type: Prognosis

Study design: Retrospective cohort

 

Investigators from the Children’s Hospital of Philadelphia and the University of Pennsylvania conducted a retrospective cohort study to determine the association between use of adjuvant corticosteroids and survival and length of hospital stay in children with bacterial meningitis.

Data from the Pediatric Health Information System (PHIS), a national administrative database containing resource utilization data from 27 freestanding, tertiary care children’s hospitals, were analyzed. Children younger than 18 years with bacterial meningitis were eligible for inclusion if they were discharged between 2001 and 2006. Children with a ventricular shunt were excluded from analysis. Patients with more than one admission with bacterial meningitis were included only for . . . [Full Text of this Article]

Susan L. Bratton, MD, MPH, FAAP
Pediatric Critical Care Medicine, Primary Children’s Medical Center, University of Utah Health Sciences Center, Salt Lake City, UT

 






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