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AAP Grand Rounds 20:17-18 (2008)
© 2008 American Academy of Pediatrics
| The first 20% of the full text of this article appears below. |
| PICO Question: In children aged 6 to 10 years, does nasal saline wash hasten the resolution of rhinitis symptoms during uncomplicated acute cold or flu and prevent reappearance of rhinitis? Question type: Intervention Study design: Prospective, multicenter, controlled, randomized trial
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In a prospective open, multicenter, randomized trial, investigators from the Czech Republic assessed the efficacy of nasal saline wash in the treatment of and subsequent prevention of uncomplicated rhinitis (common cold) in children.
Children aged 6 to 10 years were randomized to either standard treatment (defined as antipyretics, nasal decongestants, mucolytics, and/or systemic antibiotics) or standard treatment plus nasal saline, and evaluated four times over 12 weeks. Exclusion criteria included anatomic sinonasal disorders, known severe immune deficiency, and corticosteroid medication use.
Acute illness was assessed during the first two visits and no later than three weeks after initial illness, and prevention during the following two visits. Qualitative symptom scores were gauged on a 4-point Likert scale: 1 for no symptoms to 4 for severe symptoms. Health status score was also assigned on a 4-point numeric scale: 1 for cured and 4 for no change. Nasal saline was delivered in a variety of concentrations by different mechanisms. Saline
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1 Pediatric Otolaryngology, Head and Neck Surgery, Kaiser Permanente Medical Center, Oakland, CA 2 Pediatric Otolaryngology, Head and Neck Surgery, Kaiser Permanente Medical Center, Oakland, CA |
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