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This Article Full Text Full Text (PDF) Take the CME quiz: Vol. 20 No. 2, August 2008 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Villella, A. D. PubMed Articles by Villella, A. D.

AAP Grand Rounds 20:20 (2008)
© 2008 American Academy of Pediatrics

Cognitive Function Following Stem Cell Transplant in Childhood

The first 20% of the full text of this article appears below.

PICO Question: Is neurocognitive development impaired in children who undergo stem cell transplantation? Question type: Prognosis Study design: Prospective cohort

 

Investigators from St. Jude Children’s Research Hospital sought to prospectively describe cognitive and academic outcomes in survivors after pediatric hematopoietic stem-cell transplantation (SCT).

All patients undergoing SCT were eligible for the study, except for those with brain tumors or those for whom English was not their primary language. Patients were administered a battery of neurocognitive tests before transplant and then one, three, and five years later.

From 1991 to 1999, 268 patients were enrolled. Of these, 158 who were alive one year after SCT and completed at least one posttransplant assessment comprised the study cohort. Prior to SCT the estimated . . . [Full Text of this Article]

Anthony D. Villella, MD, FAAP

Pediatric Hematology/Oncology, Case Western Reserve University, Rainbow Babies & Children’s Hospital, Cleveland, OH